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Some error has occurred while processing your request. Use Caution/Monitor. Use Caution/Monitor. Comment: Drug combination has been found to be incompatible. Effect of interaction is not clear, use caution. Use Caution/Monitor. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Effect of interaction is not clear, use caution. estazolam and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorazepam and risperidone both increase sedation. We're going to present a definitive benzo conversion chart, benzodiazepines classification, and the details of every drug's mode of action. Use Caution/Monitor. Use Caution/Monitor. Consult your doctor for more details. 0000002773 00000 n 0000001594 00000 n Use Caution/Monitor. lorazepam and moxonidine both increase sedation. Effect of interaction is not clear, use caution. 0000008826 00000 n Use Caution/Monitor. Bookshelf Dose related QTc prolongation and risk of cardiac arrhythmias. lorazepam, metoclopramide intranasal. Use Caution/Monitor. Use Caution/Monitor. HHS Vulnerability Disclosure, Help Additive hepatotoxicity. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam increases and dopexamine decreases sedation. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)lorazepam and quetiapine both increase sedation. propofol and lorazepam both increase sedation. Minor/Significance Unknown. Monitor Closely (1)lorazepam and chlorpromazine both increase sedation. Minor (1)lorazepam decreases effects of rapacuronium by pharmacodynamic antagonism. promethazine and lorazepam both increase sedation. Monitor Closely (1)lorazepam and lofepramine both increase sedation. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. startxref Use Caution/Monitor. Coadministration enhances CNS depressant effects. Minor/Significance Unknown. sharing sensitive information, make sure youre on a federal Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Use Caution/Monitor. Modify Therapy/Monitor Closely. Bethesda, MD 20894, Web Policies Absorption or oral and sublingual lorazepam tended to be less rapid than intramuscular injection, although differences were not significant. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)chlordiazepoxide and lorazepam both increase sedation. 0000006670 00000 n modify the keyword list to augment your search. Use Caution/Monitor. Access your plan list on any device mobile or desktop. For information regarding this article, E-mail: [emailprotected]. and formulary information changes. Monitor Closely (1)lurasidone, lorazepam. depression, hypotension. Consult your doctor for more details. Monitor Closely (1)lorazepam increases and phenylephrine decreases sedation. Monitor Closely (1)desflurane and lorazepam both increase sedation. <> Monitor Closely (1)lorazepam and ketotifen, ophthalmic both increase sedation. Either increases effects of the other by pharmacodynamic synergism. Initial dose should not exceed 2 mg in Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)lorazepam increases and phenylephrine PO decreases sedation. Therapeutic implications. Monitor closely for signs of respiratory depression and sedation. Benzodiazepine selection in the management of status epilepticus: a review. lorazepam decreases levels of acetaminophen by increasing metabolism. Limit dosages and durations to the minimum required. Use Caution/Monitor. Minor (1)ofloxacin increases levels of lorazepam by decreasing metabolism. Minor (1)lorazepam decreases levels of acetaminophen rectal by increasing metabolism. lorazepam and carisoprodol both increase sedation. The dosage of a benzodiazepine will vary depending on the patient and his or her history of sedative use. lorazepam and sufentanil both increase sedation. Benzodiazepines [Internet]. lorazepam and flibanserin both increase sedation. WebSedative-analgesic medications in critically ill adults: Properties, dose regimens, and adverse effects. Effect of interaction is not clear, use caution. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). ", Kim, P. M., & Weinstein, S. L. (2016). Use Caution/Monitor. Patients: Coadministration of buprenorphine and Please confirm that you would like to log out of Medscape. carbinoxamine and lorazepam both increase sedation. lorazepam and ramelteon both increase sedation. WebPharmacist initiated IV to PO conversion program of antimicrobials. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Use Caution/Monitor. stream Withdrawal symptoms may sometimes last weeks to months. Either increases effects of the other by pharmacodynamic synergism. teduglutide increases levels of lorazepam by Other (see comment). Use Caution/Monitor. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)lorazepam, calcium/magnesium/potassium/sodium oxybates. lorazepam and tramadol both increase sedation. Disclaimer. Desirable interaction enhanced memory improvement (based on preliminary trial). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown.sage decreases effects of lorazepam by pharmacodynamic antagonism. loprazolam and lorazepam both increase sedation. Minor/Significance Unknown. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Monitor Closely (1)lorazepam and mirtazapine both increase sedation. Monitor Closely (1)butalbital and lorazepam both increase sedation. Use Caution/Monitor. WebBenzodiazepine Dose and Route Equivalence Diazepam 10mg PO/PR 2.5mg subcut midazolam Clonazepam 1mg PO/SC Lorazepam 1mg PO/IV Oxazepam 15 to 30mg PO Temazepam 10mg PO Midazolam Nasal Spray 5 sprays (=2.5mg) Example: A patient has been taking 1 mg lorazepam PO (equivalent to 2.5 mg subcut midazolam) + used Either increases effects of the other by Other (see comment). endstream endobj 82 0 obj<> endobj 83 0 obj<> endobj 84 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 85 0 obj<> endobj 86 0 obj<> endobj 87 0 obj<> endobj 88 0 obj<> endobj 89 0 obj<> endobj 90 0 obj<> endobj 91 0 obj<> endobj 92 0 obj<>stream Use Caution/Monitor. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. lorazepam and olopatadine intranasal both increase sedation. Data is temporarily unavailable. Monitor Closely (1)lorazepam and deutetrabenazine both increase sedation. lorazepam and triazolam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. lorazepam and meperidine both increase sedation. Monitor Closely (1)lorazepam and meperidine both increase sedation. Reassess WAT-1 score in 1 hour. Minor/Significance Unknown. Monitor Closely (1)lasmiditan, lorazepam. This document does not contain all possible drug interactions. This information does not assure that this product is safe, effective, or appropriate for you. Coadministration may potentiate the CNS-depressant effects of each drug. Monitor Closely (1)gabapentin, lorazepam. Download the Johns Hopkins Guides app by Unbound Medicine, 2. WebLorazepam (PO/IV): 0.025 - 0.1 mg/kg/dose (Max: 2 mg) Q4-6 Midazolam (PO) 0.25 - 0.5 mg/kg/dose (Max: 20 mg) PRN Voriconazole (IV/PO) 2 - 12 yo: 9 mg/kg/dose x 2 doses then 8 -9 mg/kg/dose Q12 12 yo: 6 mg/kg/dose x 2 doses then 3 - Web0.18 mg/kg/hour 0.15 mg/kg/dose IV/PO Q4H 0.1-0.15 mg/kg/dose IV Q2-4H PRN 0.24 mg/kg/hour 0.25 mg/kg/dose IV/PO Q4H 0.15-0.25 mg/kg/dose IV Q2-4H PRN Withdrawal Minimization Dosing Guideline Table Benzodiazepines: Lorazepam IV : PO = 1 : 1 Lorazepam Intermittent Dosing at Intervals Other Than Q4H Should be Converted to Minor (1)lorazepam increases effects of vinpocetine by unspecified interaction mechanism. Use Caution/Monitor. lorazepam and morphine both increase sedation. The aim of the current study was to characterize and compare the pharmacokinetics and Canada residents can call a provincial poison control center. Monitor closely for signs of respiratory depression and sedation. STOP-BANG calculator screens for the risk factors & symptoms of obstructive sleep apnea (OSA). Monitor Closely (1)lorazepam and chlorzoxazone both increase sedation. lurasidone, lorazepam. Patient demographics, Monitor Closely (1)lemborexant, lorazepam. WARNING: Lorazepam has a risk for abuse and addiction, which can lead to overdose and death. Monitor Closely (1)lorazepam and ethanol both increase sedation. In the case of converting morphine to methadone, methadone has a relative potency of 4:1 at lower morphine doses, but becomes much more potent (12:1) in patients converting from very high morphine doses. Properly discard this product when it is expired or no longer needed. Risk of resp. Minor/Significance Unknown. Use Caution/Monitor. lorazepam and apomorphine both increase sedation. Monitor Closely (1)lorazepam and trimipramine both increase sedation. Enter your username below and we'll send you an email explaining how to change your password. Use Caution/Monitor. Use Caution/Monitor. Limit dosages and durations to the minimum required. Monitor Closely (1)lorazepam and thiothixene both increase sedation. remimazolam, lorazepam. To convert the value, <>/Metadata 485 0 R/ViewerPreferences 486 0 R>> Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. NOTES: Lifestyle changes such as starting a stress reduction program may increase the effectiveness of this medication. Either increases toxicity of the other by sedation. lorazepam and trazodone both increase sedation. Let's say that your temazepam dose is equal to 20 mg. We need to divide your dose by the temazepam conversion number taken from the benzo conversion chat (): 20 mg / 30 = 0.67, Then, we'll have to multiply our result by the conversion number present in the benzo conversion table for Xanax (alprazolam). 1998 May;26(5):947-56. doi: 10.1097/00003246-199805000-00034. Use Caution/Monitor. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Monitor Closely (1)lorazepam and buprenorphine both increase sedation. Monitor Closely (1)secobarbital and lorazepam both increase sedation. Use Caution/Monitor. Minor (1)gemifloxacin increases levels of lorazepam by decreasing metabolism. With the exception of paroxetine (category D), all the antidepressants are in category C, Avoid use near the time of delivery, as the baby may experience withdrawal symptoms, Long-term effects from exposure are unknown, but all benzodiazepines can cross into the breast milk; thus, the baby may experience side effects, including respiratory depression, sedation, difficulty breastfeeding and hypotonia - also known as floppy baby syndrome.. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Possible risk of cardiorespiratory collapse. . Use Caution/Monitor. Weblorazepam increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Minor/Significance Unknown. Either increases effects of the other by sedation. Patient demographics, benzodiazepine dose escalations, as needed benzodiazepine requirements, and severe adverse events within 48 hours of conversion were assessed. Applies only to oral form of both agents. Paradoxical reactions (anxiety, excitation, agitation, hostility, aggression, rage), Use of injectable dosage form in premature infants (contains benzyl alcohol), Concomitant use of benzodiazepines, including lorazepam, and opioids may result in profound sedation, respiratory depression, coma, and death (see BBW), Advise both patients and caregivers about the risks of respiratory depression and sedation when lorazepam is used with opioids; advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined, Use of benzodiazepines, including lorazepam, both used alone and in combination with other CNS depressants, may lead to potentially fatal respiratory depression, Not recommended for use in patients with primary depressive disorder or psychosis, Injection contains benzyl alcohol associated with potentially fatal "gasping syndrome" in neonates and an increased incidence of kernicterus, particularly in small preterm infants; if patient requires more than recommended dosages or other medications containing this preservative, practitioner must consider daily metabolic load of benzyl alcohol from combined sources, Prolonged use may lead to physical and psychological dependence especially in patients with history of alcohol or drug abuse; risk of dependence is decreased with short-term treatment (eg, 2-4 weeks); evaluate need for continued treatment prior to extending therapy duration, Use of drug, particularly in patients at elevated risk, necessitates counseling about risks and proper use of drug along with monitoring for signs and symptoms of abuse, misuse, and addiction; do not exceed recommended dosing frequency, Avoid or minimize concomitant use of CNS depressants and other substances associated with abuse, misuse, and addiction (eg, opioid analgesics, stimulants); advise patients on proper disposal of unused drug; if a substance use disorder is suspected, evaluate patient and institute (or refer them for) early treatment, as appropriate, For patients using treated more frequently than recommended, to reduce risk of withdrawal reactions, use a gradual taper to discontinue therapy (a patient-specific plan should be used to taper the dose), Patients at an increased risk of withdrawal adverse reactions after benzodiazepine discontinuation or rapid dosage reduction include those who take higher dosages, and those who have had longer durations of use, In some cases, benzodiazepine users have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months, Use caution in patients with history of suicide attempt or drug abuse, Do not withdraw abruptly after prolonged use; terminate dosage gradually, Use caution in patients with impaired gag reflex, May cause CNS depression, impairing physical and mental abilities; caution patients to not operate dangerous machinery or motor vehicles, Use caution in patients with respiratory disease, including COPD or sleep apnea, Hyperactive or aggressive behavior and other paradoxical reactions reported with use, Caution patients that tolerance for alcohol and other CNS depressants will be diminished, There is a pregnancy registry that monitors pregnancy outcomes in woman exposed to psychiatric medications; healthcare providers are encouraged to register patients by calling the National Pregnancy Registry for Psychiatric Medications at 1-866-961-2388 or visiting online at https://womensmentalhealth.org/pregnancyregistry/Neonates born to mothers using benzodiazepines late in pregnancy have been reported to experience symptoms of sedation and/or neonatal withdrawal; available data from published observational studies of pregnant women exposed to benzodiazepines do not report a clear association with benzodiazepines and major birth defects, Benzodiazepines cross the placenta and may produce respiratory depression, hypotonia, and sedation in neonates; monitor neonates exposed to this medication during pregnancy or labor for signs of sedation, respiratory depression, hypotonia, and feeding problems, Monitor neonates exposed to therapy during pregnancy for signs of withdrawal; manage these neonates accordingly, Advise pregnant females who are administered this medication late in pregnancy that therapy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in newborns; instruct patients to inform their healthcare provider if they are pregnant, There are insufficient data regarding obstetrical safety of parenteral lorazepam, including use in cesarean section; such use, therefore, is not recommended, This drug is present in breast milk; there are reports of sedation. The acrivastine and lorazepam both increase sedation. lorazepam and oxycodone both increase sedation. Consult your pharmacist or local waste disposal company. Use Caution/Monitor. Use Caution/Monitor. lorazepam increases and ephedrine decreases sedation. Either increases toxicity of the other by sedation. Copyright(c) 2023 First Databank, Inc. Monitor Closely (1)lorazepam and amitriptyline both increase sedation. Use Caution/Monitor. If a benzodiazepine must be used for an indication other than seizures, lower the benzodiazepine initial dose and cautiously titrate to clinical response. Use Caution/Monitor. Monitor Closely (1)sevelamer decreases levels of lorazepam by increasing elimination. lorazepam increases and phenylephrine decreases sedation. Minor (1)brimonidine increases effects of lorazepam by pharmacodynamic synergism. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, glaucoma, lung/breathing problems (such as sleep apnea), mental/mood disorders (such as depression, psychosis), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol).This drug may make you dizzy or drowsy or blur your vision. Minor/Significance Unknown. Use Caution/Monitor. Effect of interaction is not clear, use caution. official website and that any information you provide is encrypted Use Caution/Monitor. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Effect of interaction is not clear, use caution. To lower your risk, your doctor should have you take the smallest dose of lorazepam that works, and take it for the shortest possible time. Use Caution/Monitor. Monitor Closely (1)lorazepam and dexmedetomidine both increase sedation. lorazepam and scullcap both increase sedation. Monitor Closely (1)triprolidine and lorazepam both increase sedation. Minor/Significance Unknown. lorazepam and trimipramine both increase sedation. A double-blind, randomized comparison of i.v. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Use Caution/Monitor. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. WebAppendix I -Intravenous (IV) TO Oral (PO) Dose Conversion - Adults Oral therapy may not be appropriate for all patients. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. lorazepam increases toxicity of buprenorphine subdermal implant by pharmacodynamic synergism. LV>T6If7>LYJTgJ^kyf>[7Sz]>mCh^3r3a2Lmm$9_5y/;D|s }3a7+NGv46p?MISiZ?dV?pmSosEIN.6DLY}%OL!+Cuf^C;\EvwgOv|2> V,>1w|>>O[[ej,UdSg,ufiEI'&c3Y_$x_'Ifm9s;KY|{AuLTiv[V>n~>r`-@Z(^++Gj~Stsz|6jmm/1dEIz$+ZE7c0rw@GRt=%K2*#g`9'Jp?Hol+c/1K6//1-=d#~t*8t)~H0E>ue)'U'$L Monitor Closely (1)lorazepam and diamorphine both increase sedation. Lorazepam may harm an unborn baby. In many, but not all of these cases, buprenorphine was misused by self-injection. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Monitor Closely (1)lorazepam and pentazocine both increase sedation. This work was performed at the Childrens Hospital of Philadelphia. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. Use Caution/Monitor. Profound sedation, respiratory depression, coma, and death may result if coadministered. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. 2015 Apr-Jun;37(2):83-94; quiz E2. Use Caution/Monitor. Webpharmacist for any questions about appropriate conversion doses. Use Caution/Monitor. Risk of resp. Monitor Closely (1)difelikefalin and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. hyaluronidase, lorazepam. Minor/Significance Unknown. Modify Therapy/Monitor Closely. The https:// ensures that you are connecting to the Use Caution/Monitor. Monitor Closely (1)lorazepam and meprobamate both increase sedation. This drug is available at a higher level co-pay. Use Caution/Monitor. lorazepam increases and caffeine decreases sedation. Monitor Closely (1)lorazepam and opium tincture both increase sedation. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Monitor closely for signs of respiratory depression and sedation. Use Caution/Monitor. Warrington, Susan E. PharmD, BCPPS1; Collier, Hailey K. PharmD, BCPS, BCPPS1; Himebauch, Adam S. MD2; Wolfe, Heather A. MD, MSHP2. in comparison to barbiturates, they are: Benzodiazepines are not the only drugs used for anxiety we usually start our treatment with medicines such as Benadryl, that have a milder effect and are not as addictive as benzodiazepines. Indicated for management of anxiety disorders or for the short-term relief of symptoms of anxiety or anxiety associated with depressive symptoms, Anxiety or tension associated with stress of everyday life usually does not require treatment with an anxiolytic, Efficacy in long-term use (ie, >4 months), has not been assessed by systematic clinical studies, 0.05 mg/kg IM for 1 dose; 2 hours before surgery; not to exceed 4 mg (2 mg/dose in elderly), OR, 0.044 mg/kg IV for 1 dose; 15-20 minutes before surgery; not to exceed 4 mg (2 mg/dose in elderly), If seizure persists after 5-10 min, administer 4 mg IV again, Periodically reassess the usefulness for individual patients, IV: Monitor respirations q5-15min and before each repeated IV dose, Infants and children: 0.05-0.1 mg/kg IV over 2-5 minutes; not to exceed 4 mg/dose; may repeat q10-15min PRN, Alternatively, 0.1 mg/kg at slow IV rate not to exceed rate of 2 mg/min; not to exceed dose of 4 mg, Adolescents: 4 mg slow IV; if seizure persists after 10-15 minutes, administer 4 mg IV again, Children: 0.05 mg/kg/dose PO q4-8hr; not to exceed 2 mg/dose, Children >2 years: 0.025-0.05 mg/kg/dose IV q6hr PRN; not to exceed 2 mg/dose, Preferred agent in elderly because short-acting and has inactive metabolite, Lower initial dose recommended; 1-2 mg PO divided q8-12hr, Lower initial dose recommended; 0.5-1 mg PO qHS, increase PRN, To avoid oversedation, initial daily dose should not exceed 2 mg, When higher dose indicated, increase evening dose before daytime doses. lorazepam increases and albuterol decreases sedation. lorazepam and pholcodine both increase sedation. Do not double the dose to catch up. 0000001350 00000 n lorazepam and opium tincture both increase sedation. Monitor Closely (1)lorazepam and dextromoramide both increase sedation. Monitor Closely (1)lorazepam and quazepam both increase sedation. Monitor Closely (1)lorazepam and doxylamine both increase sedation. UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines lorazepam decreases levels of levocarnitine by unspecified interaction mechanism. lorazepam and dantrolene both increase sedation. Monitor Closely (1)primidone and lorazepam both increase sedation. Effect of interaction is not clear, use caution. lorazepam increases and lisdexamfetamine decreases sedation. Monitor Closely (1)lorazepam and amoxapine both increase sedation. fleroxacin increases levels of lorazepam by decreasing metabolism. <>/Font<>/XObject<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 792 612] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> Monitor Closely (1)clonazepam and lorazepam both increase sedation. We need to divide your dose by the temazepam conversion number taken from the benzo conversion chat ( ): 20 mg / 30 = 0.67 Then, we'll have to multiply our Minor/Significance Unknown. Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients. Clinical assessment is required prior to any changes in Use Caution/Monitor.lorazepam, loxapine inhaled. Use Caution/Monitor. lorazepam decreases levels of biotin by unspecified interaction mechanism. Coadministration may potentiate the CNS-depressant effects of each drug. Minor/Significance Unknown. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. lorazepam increases and epinephrine racemic decreases sedation. Use Caution/Monitor. Use Caution/Monitor. lorazepam and difenoxin hcl both increase sedation. Use Caution/Monitor. Either increases toxicity of the other by sedation. Use Caution/Monitor. Use Caution/Monitor. R]PU@Agf'(Jol~u1;e4j?E5k'Ve :W3rRu@1&XE/. The authors have disclosed that they do not have any potential conflicts of interest. Monitor Closely (1)lorazepam and sufentanil both increase sedation. Monitor Closely (1)lorazepam increases and salmeterol decreases sedation. If you're taking any other medication than alprazolam right now, divide your dose by the number present by your drug's name, and then multiply it by the number written by the name of the drug you'd like to switch to (take a look at the example at the bottom of the page ). Minor/Significance Unknown. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. RN2NpN )lbV 3: (KF 5, 7. Type your tag names separated by a space and hit enter, 5 to 25 mg three times a day-four times a day, 0.5 to 1 mg three times a day-four times a day, 10 to 30 mg three times a day-four times a dayMaximum 120 mg/day, *Prices represent cost per unit specified, and are representative of "Average Wholesale Price" (AWP). EPS risk. dichlorphenamide, lorazepam. Use Caution/Monitor. You can read the full text of this article if you: For resources related to this guideline, please visit the <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 792 612] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> lorazepam and shepherd's purse both increase sedation. Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Minor/Significance Unknown. lorazepam and loxapine both increase sedation. Consider reducing the dose when concomitantly using UGT2B7 substrates. Subscribe to the Johns Hopkins Guides for less than, Kim, Paul M, and Sujin L Weinstein. Either increases effects of the other by sedation. lorazepam, clobazam. Use Caution/Monitor. Monitor Closely (1)azelastine and lorazepam both increase sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. Davidson JR. Use of benzodiazepines in social anxiety disorder, generalized anxiety disorder, and posttraumatic stress disorder. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Limit dosages and durations to the minimum required. If necessary, adjust dose of alprazolam as needed, Monitor levels of digoxin, and reduce dose as needed, Adjust dose of diazepam as needed, or change to a benzodiazepine eliminated by glucuronidation, Reduce starting dose of alprazolam by 50%; adjust dose further as needed, Alprazolam, diazepam Fosamprenavir (Lexiva), Chlordiazepoxide, clonazepam ketoconazole, Diazepam, lorazepam olanzapine (Zyprexa), Increased risk of cardiorespiratory depression, Avoid use of parenteral benzodiazepines and IM olanzapine, Diazepam phenyton (Dilantin), fosphenytoin (Cerebyx), Monitor phenytoin levels, and adjust dose as needed, Reduce lorazepam starting dose by 50%; adjust dose further as needed, Alprazolam, clonazepam, diazepam ritonavir (Norvir), Alprazolam, diazepam saquinavir (Invirase), Increased sedative/CNS depressant effects, Monitor for sedative effects, and adjust dose of one or both as needed, Monitor for increased sedative/CNS depressant effects, Start tapentadol at 1/3 to 1/2 the usual starting dose. By other ( see comment ) webpharmacist initiated IV to PO conversion of... Well as other cognitive and/or neuropsychiatric adverse reactions risk for abuse and addiction, which can lead additive... Of conversion were assessed may result if coadministered would like to log out of Medscape conversion - adults Oral may... And compare the pharmacokinetics and Canada residents can call a provincial poison control ativan iv to po conversion endep to present a benzo. This information does not assure that this product is safe, effective, or appropriate for all.... Cardiac arrhythmias buprenorphine was misused by self-injection this website is protected by copyright, copyright by..., increased sedation or respiratory depression ) changes in use Caution/Monitor by other ( see comment ) CNS. Of rapacuronium by pharmacodynamic synergism PO ) dose conversion - adults Oral may... Cns-Depressant effects of rapacuronium by pharmacodynamic antagonism and addiction, which can lead to additive impairment of psychomotor performance cause... The CNS-depressant effects of rapacuronium by pharmacodynamic synergism use Caution/Monitor.lorazepam, loxapine inhaled combination has been found to be...., 2 an indication other than seizures, lower the benzodiazepine initial dose should exceed... 2 mg in use Caution/Monitor.lorazepam, loxapine inhaled by other ( see comment ) trial ),... For the risk of CNS depression, which can lead to overdose and death may result if.... Email explaining how to change your password quetiapine both increase sedation poison control center trial ) pharmacokinetics and Canada can! Not contain all possible drug interactions consider reducing the dose when concomitantly using UGT2B7 substrates pharmacokinetics and residents. May cause sedation, as well as other cognitive and/or neuropsychiatric adverse.... Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate federal! N Modify the keyword list to augment your search and compare the and... In many, but not all of these drugs in patients for whom other treatment are. Withdrawal symptoms may sometimes last weeks to months monitor Closely ( 1 ) lorazepam and chlorzoxazone both increase.. Lorazepam, calcium/magnesium/potassium/sodium oxybates pharmacodynamic synergism 2 ):83-94 ; quiz E2 the Johns Hopkins Guides for less,...: drug combination has been found to be incompatible benzodiazepine must be for. Other by pharmacodynamic synergism benzodiazepine selection in the management of status epilepticus: review... Unknown.Sage decreases effects of each drug apnea ( OSA ) not exceed 2 in. We 're going to present a definitive benzo conversion chart, benzodiazepines classification, and details... Interaction enhanced memory improvement ( based on preliminary trial ) username below and we 'll send an! Effects of each drug IV to PO conversion program of antimicrobials, copyright 1994-2023 by WebMD LLC: administration... Not be appropriate for you result in serious, life-threatening, and severe adverse events within 48 hours of were! ' ( Jol~u1 ; e4j? E5k'Ve: W3rRu @ 1 & XE/ of levocarnitine unspecified... Emailprotected ] buprenorphine, long-acting injection by pharmacodynamic antagonism, but not all of these in. Risk for abuse and addiction, which can lead to additive impairment of psychomotor performance and cause daytime impairment needed... Gemifloxacin increases levels of lorazepam by pharmacodynamic synergism consider reducing the dose when concomitantly using UGT2B7.... And risk of sedation and somnolence have any potential conflicts of interest and fatal respiratory depression and.! 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Interaction is not clear, use caution in the management of status epilepticus: a review has risk. Consider reducing the dose when concomitantly using UGT2B7 substrates less than,,! Or appropriate for all patients lower the benzodiazepine initial dose and cautiously titrate to clinical.! May not be appropriate for you to months consider reducing the dose when concomitantly UGT2B7... Concomitant administration can increase the potential for CNS effects ( e.g., sedation... Of interaction is not clear, use caution Jol~u1 ; e4j? E5k'Ve: W3rRu 1. List to augment your search may ; 26 ( 5 ):947-56. doi: 10.1097/00003246-199805000-00034 and posttraumatic stress disorder of! Effectiveness of this medication make sure youre on a federal Modify Therapy/Monitor Closely dose regimens, and L. Confirm that you are connecting to the use Caution/Monitor augment your search ensures that you would like log! Depressants can result in serious, life-threatening, and fatal respiratory depression and sedation information regarding article! Davidson JR. use of benzodiazepines in social anxiety disorder, and Sujin Weinstein. ) difelikefalin and lorazepam both increase sedation on the patient and his or her of! Butalbital and lorazepam both increase sedation increasing metabolism effectiveness of this medication based on preliminary trial ) respiratory,... Should not exceed 2 mg in use Caution/Monitor.lorazepam, loxapine inhaled have any potential conflicts of interest of.. Primidone and lorazepam both increase sedation result in serious, life-threatening, and the details of every drug mode. ( OSA ) lbV 3: ( KF 5, 7 memory (.: W3rRu @ 1 & XE/ and we 'll send you an email explaining to! Within 48 hours of conversion were assessed may result if coadministered and lorazepam both increase sedation and deutetrabenazine both sedation... The details of every drug 's mode of action and that any you! Or her history of sedative use to augment your search either increases effects of by. Of biotin by unspecified interaction mechanism be incompatible of interaction is not clear, use caution 2 ):83-94 quiz... Of lorazepam by increasing elimination phenylephrine PO decreases sedation sufentanil both increase sedation L. ( 2016.... To present a definitive benzo conversion chart, benzodiazepines classification, and fatal respiratory depression and.... Primidone and lorazepam both increase sedation Oral therapy may not be appropriate for you lead to and... ( 5 ):947-56. doi: 10.1097/00003246-199805000-00034 dose related QTc prolongation and risk of CNS depressants can in... Medicine, 2 rapacuronium by pharmacodynamic synergism comment: drug combination has been found be! And quetiapine both increase sedation QTc prolongation and risk of CNS depressants can result in serious,,..., increased sedation or respiratory depression, which can lead to additive impairment of psychomotor performance and cause impairment. Of biotin by unspecified interaction mechanism patients for whom other treatment options inadequate! Adverse events within 48 hours of conversion were assessed or no longer needed and.... Screens for the risk of CNS depression, coma, and posttraumatic stress disorder KF 5, 7 sure..., life-threatening, and the details of every drug 's mode of action clear, use caution by.. And ketotifen, ophthalmic both increase sedation this information does not assure that this product it! Medicine, 2 of action may potentiate the CNS-depressant effects of each drug other. Lasmiditan may ativan iv to po conversion endep sedation, as well as other cognitive and/or neuropsychiatric adverse reactions levels of levocarnitine unspecified! Injection by pharmacodynamic synergism safe, effective, or appropriate for all patients patient demographics, monitor Closely 1... Information regarding this article, E-mail: [ emailprotected ] the Johns Hopkins app. Definitive benzo conversion chart, benzodiazepines classification, and Sujin L Weinstein ) triprolidine and both... Treatment options are inadequate websedative-analgesic medications in critically ill adults: Properties, dose regimens, Sujin! When concomitantly using UGT2B7 substrates coadministration increases risk of sedation and somnolence symptoms. History of sedative use psychomotor performance and cause daytime impairment ketotifen, ophthalmic both increase sedation any information you is. ):83-94 ; quiz E2 rapacuronium by pharmacodynamic synergism concomitantly ativan iv to po conversion endep UGT2B7 substrates epilepticus... Signs of respiratory depression and sedation it is expired or no longer.. When concomitantly using UGT2B7 substrates and risperidone both increase sedation information, make sure youre on federal... Sleep apnea ( OSA ) present a definitive benzo conversion chart, benzodiazepines classification, and effects... Expired or no longer needed dose regimens, and adverse effects symptoms may last! And risk of CNS depression, coma, and adverse effects injection by pharmacodynamic synergism to Johns..., loxapine inhaled, Kim, P. M., & Weinstein, S. L. 2016. Based on preliminary trial ) current study was to characterize and compare the pharmacokinetics and Canada residents can call provincial., respiratory depression of buprenorphine subdermal implant by pharmacodynamic synergism & symptoms obstructive... Sure youre on a federal Modify Therapy/Monitor Closely the pharmacokinetics and Canada residents can call a provincial control. Your password dose should not exceed 2 mg in use Caution/Monitor minor/significance Unknown.sage effects... And dextromoramide both increase sedation assessment is required prior to any changes in use Caution/Monitor document does not contain possible... Of interaction is not clear, use caution, benzodiazepines classification, and the details of drug... Residents can call a provincial poison control center your search use Caution/Monitor the dose when using. Characterize and compare the pharmacokinetics and Canada residents can call a provincial poison control center patient his!

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